minor groove

Review on DNA minor groove binders as antitumor drugs

抗肿瘤药物DNA小沟区结合剂的研究进展

Our simulation results indicated that a DNA molecule bound by a reversible amidine produced a narrow and deep minor groove .

模拟结果表明DNA与可逆脒小分子的结合会产生一个又窄又深的小沟。

Simulation results were consistent with experimental results , showing that EGCG is connected in DNA G-C rich area with minor groove mode . 4 .

模拟的结果与实验一致，且显示出EGCG以小沟槽模式结合在DNA的G-C富裕区。

Synthetic polyamides can bind to specific nucleotide sequences in the minor groove of double-helical DNA with high affinity and specificity and influence gene expression . PIP are chemical compounds that are completely resistant to nucleases and do not require particular delivery systems .

研究表明PIP能在双螺旋DNA小沟处与特异性核酸序列紧密结合，影响基因表达；同时，PIP可抵抗核酸酶的降解，不需要特殊的转运系统。